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It also activates focal adhesion kinase (FAK) and paxillin signalling, facilitating cell migration to wound sites

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Due to the rapid proliferation and metabolism of tumor cells, glycolysis is highly active, and the tumor microenvironment (TME) often exhibits characteristics of hypoxia and glucose deprivation

22 Additionally, K673-peptide-3# (K673-pe), a peptidic inhibitor, suppresses MRE11 K673 lactylation to block DSB repair-mediated HR hyperactivation and sensitize CRC cells to chemotherapy, resulting in a synergistic tumor-suppressive effect